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KMID : 0881720140290040305
Journal of Food Hygiene and Safety
2014 Volume.29 No. 4 p.305 ~ p.311
The Analysis for Minimum Infective Dose of Foodborne Disease Pathogens by Meta-analysis
Park Myoung-Su

Bahk Gyung-Jin
Cho Joon-Il
Lee Soon-Ho
Abstract
Minimum infective dose (MID) data has been recognized as an important and absolutely needed in quantitative microbiological assessment (QMRA). In this study, we performed a comprehensive literature review and meta-analysis to better quantify this association. The meta-analysis applied a final selection of 82 published papers for total 12 species foodborne disease pathogens (bacteria 9, virus 2, and parasite 1 species) which were identified and classified based on the dose-response models related to QMRA studies from PubMed, ScienceDirect database and internet websites during 1980-2012. The main search keywords used the combination ¡°food¡±, ¡°foodborne disease pathogen¡±, ¡°minimum infective dose¡±, and ¡°quantitative microbiological risk assessment¡±. The appropriate minimum infective dose for B. cereus, C. jejuni, Cl. perfringens, Pathogenic E. coli (EHEC, ETEC, EPEC, EIEC), L. monocytogenes, Salmonella spp., Shigella spp., S. aureus, V. parahaemolyticus, Hepatitis A virus, Noro virus, and C. pavum were 105 cells/g (fi = 0.32), 500 cells/g (fi = 0.57), 107 cells/g (fi = 0.56), 10 cells/g (fi = 0.47) / 108 cells/g (fi = 0.71) / 106 cells/g (fi = 0.70) / 106 cells/g (fi = 0.60), 102
~103 cells/g (fi = 0.23), 10 cells/g (fi = 0.30), 100 cells/g (fi = 0.32), 105 cells/g (fi = 0.45), 106 cells/g (fi = 0.64), 10~102 particles/g (fi = 0.33), 10 particles/g (fi = 0.71), and 10~102 oocyst/g (fi = 0.33), respectively. Therefore, these results provide the preliminary data necessary for the development of foodborne pathogens QMRA.
KEYWORD
foodborne disease, meta-analysis, quantitative microbiological risk assessment, minimum infective dose
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